| You are picking up electrical noise from the internals of the PC. You don't hear it on typical PC speakers because they are pretty low quality and pretty insensitive, but you are feeding it into a sensitive amplifier. You aren't feeding it into a guitar pick up input are you? If you are, then it is no wonder you are getting problems - the impedance matching will be wrong for a start, and it will be FAR too sensitive. You should be using an 'ordinary' auxiliary input on the guitar amp, or feeding it via a mixing desk with an aux input.
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