I'm no audiophile myself, despite having been a semi-professional musician. I generally fiddle until I am happy enough and go with that.
What:
Speakers - Edifier RT1600
Headphones - Corsair Vengeance 1500 v2
Why:
Speakers - They only cost me £50 for 2.1 sound in a medium-sized home office and are WICKED.
Headphones - My Plantronics 780s karked it, as they generally do and I needed a hard-weraing replacement. The Vengeance fit the bill and I've actually had better quality sound, even though they're 7.1 USB audio.