The top is pre-drilled for 280mm (or 420mm) radiators as well as 240, 360, and 480mm radiators
Assuming 120mm fans:
3 in front, 4 up top, 1 in the rear.
Hard drive cages can also feature a 2nd 120mm mount on the other side, for push-pull hdd cage cooling.
Assuming 140mm fans:
0 in front, 3 up top, 1 in the rear.
The bottom chamber can be used to affect internal temps as well, if you want to use one of the bottom side radiator mounts as a cold air intake, it would add a lot more fresh air to the main chamber.
Each bottom side mount can fit either 4 x 120 or 3 x 140, but the PSU encroaches into that area on one side.