Hmm that doesn't make sense but the minimum multiplier for E6750 and Q6600 under EIST is 6X, with a Q6600 the default FSB is 266 (266 x 6 = 1596), for E6750 it is 333 (333 x 6 = 1998 Mhz).
Assuming above is reason for clockage then as for why your E6750 originally clocked at 1.6 Ghz even under load I would guess your motherboard BIOS did not recognise the E6750 settings out of the box (P5K Deluxe is same PCB design as the P5K-E I think you have and the release BIOS didn't support E6x50 series CPUs) and may use the lowest available multiplier and default FSB until you manually correct it.
Ram to FSB ratio shouldn't impact EIST, if it is in your case I don't know why that would be so