MSAccess MDB corruption

[harveypoole]

Migrated VB6 (MS Access 2003) based application from Windows Server 2008 Enterprise to Windows Server 2008 R2. The application is accessed via network share from Citrix XenApp.
Since the move, we have had an almost daily corruption issue in one of the mdb files. Does WIN2K8 R2 behave differently than WIN2K8 Enterprise in terms of handling open sessions? The Citrix servers reboot nightly – some end-users are bad about logging out correctly and leaving sessions idle.
Is there a file monitoring tool, script or some other method to monitor the file for corruption and send an e-mail notification?

[shaithis]

My first thought would be "Does the 2008 R2 box have remote differential compression enabled while the 2008 box didn't?"

The only other thing I can think of is a corruption in the file system, have you run chkdsk on the new server?

AFAIK, there shouldn't be anything fundamentally different in regards to file-handling between 2008 and R2.