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Thread: Cannabis, ladies take note

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    Seething Cauldron of Hatred TheAnimus's Avatar
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    Cannabis, ladies take note

    http://www.ncbi.nlm.nih.gov/pubmed/22963825

    Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.

    Despite what the title says it is possible for men to get breast cancer too, just about 100 times less likely.
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    aidanjt (19-09-2012),ehhhhhhh (19-09-2012),MadduckUK (26-09-2012)

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    Re: Cannabis, ladies take note

    a reefer a day keeps the doctor away... sort of ha

    B@

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    Re: Cannabis, ladies take note

    So you're saying I need to get my wife stoned all the time, for her own good?

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    Grumpy and VERY old :( g8ina's Avatar
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    Re: Cannabis, ladies take note

    OK chaps, gotta be careful what we say on this subject, and note that HEXUS cannot condone the illegal use of controlled drugs no matter how wonderful they may be
    Last edited by peterb; 26-09-2012 at 12:22 PM. Reason: Clarity
    Cheers, David



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    Moosing about! CAT-THE-FIFTH's Avatar
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    Re: Cannabis, ladies take note

    Quote Originally Posted by Smudger View Post
    So you're saying I need to get my wife stoned all the time, for her own good?
    Probably not in this case. For the compound to be truely effective it needs to be targeted to the desired cells/tissues first with high efficacy. I also doubt smoking it will be any good especially since heat might actually degrade it too.

    From the abstract:
    "Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant"

    An extract from the plant(or one produced via alternate means) will probably be developed in pill or injection form,which solves the need to smoke plant materials. However this depends on how well it will do outside of the lab. It will be quicker and more efficient and avoids things like tar which you get with smoking dried plant leaves. Its no point trying to reduce the likelihood of one form of cancer to then increase the likelihood of getting another.
    Last edited by CAT-THE-FIFTH; 26-09-2012 at 12:10 PM.

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    Re: Cannabis, ladies take note

    they need to make THC containing capsules for e-cigarettes tbh.
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    Re: Cannabis, ladies take note

    Quote Originally Posted by CAT-THE-FIFTH View Post
    Probably not in this case. For the compound to be truely effective it needs to be targeted to the desired cells/tissues first with high efficacy. I also doubt smoking it will be any good especially since heat might actually degrade it too.

    From the abstract:
    "Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant"

    An extract from the plant(or one produced via alternate means) will probably be developed in pill or injection form,which solves the need to smoke plant materials. However this depends on how well it will do outside of the lab. It will be quicker and more efficient and avoids things like tar which you get with smoking dried plant leaves. Its no point trying to reduce the likelihood of one form of cancer to then increase the likelihood of getting another.
    They already have extracts ( or synthetic cannaboids ) , but you'd have fat chance of getting it on nhs because its costs so much to buy .

    I have Peripheral Neuropathy myself and theres no one way in hell I'll get it unless I pay private , see for yourself what folk are paying .
    ( Thanks Big Pharma !! )

    m

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    Re: Cannabis, ladies take note

    Quote Originally Posted by CAT-THE-FIFTH View Post
    Probably not in this case. For the compound to be truely effective it needs to be targeted to the desired cells/tissues first with high efficacy. I also doubt smoking it will be any good especially since heat might actually degrade it too.

    From the abstract:
    "Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant"

    An extract from the plant(or one produced via alternate means) will probably be developed in pill or injection form,which solves the need to smoke plant materials. However this depends on how well it will do outside of the lab. It will be quicker and more efficient and avoids things like tar which you get with smoking dried plant leaves. Its no point trying to reduce the likelihood of one form of cancer to then increase the likelihood of getting another.
    A few months back I have found a study, comparing the effects of a syntetic CBD/THC drug to the raw plant itself (inhaling it in different ways like through a vapourizer (200-250C). They found that the natural substance was a lot more effective overall.

    I'll try to find it again and post it when I have time. As I remember nature published it a while back.

    FYI, the leaves of the plant is useless. Many people with severe illnesses use the female plants' flowers to provide relief. And they do it via smoking and vaporising.

    It is plausible that many countries started to focus on the true potential of these plants and try to kill the baseless propaganda against it.

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    Re: Cannabis, ladies take note

    Quote Originally Posted by ehhhhhhh View Post
    A few months back I have found a study, comparing the effects of a syntetic CBD/THC drug to the raw plant itself (inhaling it in different ways like through a vapourizer (200-250C). They found that the natural substance was a lot more effective overall.

    I'll try to find it again and post it when I have time. As I remember nature published it a while back.

    FYI, the leaves of the plant is useless. Many people with severe illnesses use the female plants' flowers to provide relief. And they do it via smoking and vaporising.

    It is plausible that many countries started to focus on the true potential of these plants and try to kill the baseless propaganda against it.
    If your interested in this stuff check out MAPS research in LSD,MDMA, Pot etc

    The only time I had relief in my life from PN ( which was caused by medication now banned I might add ) was taking Pot or Shrooms ,nothing even comes close ( Ive tried pretty much everything for PN )

    m
    Last edited by melon; 26-09-2012 at 12:48 PM.

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    Re: Cannabis, ladies take note

    Quote Originally Posted by ehhhhhhh View Post
    A few months back I have found a study, comparing the effects of a syntetic CBD/THC drug to the raw plant itself (inhaling it in different ways like through a vapourizer (200-250C). They found that the natural substance was a lot more effective overall.

    I'll try to find it again and post it when I have time. As I remember nature published it a while back.

    FYI, the leaves of the plant is useless. Many people with severe illnesses use the female plants' flowers to provide relief. And they do it via smoking and vaporising.

    It is plausible that many countries started to focus on the true potential of these plants and try to kill the baseless propaganda against it.
    The synthetic cannabinoid used was not actually the same as the one found in the plant IIRC,and moreover as time progresses expect more headway to be made in making better synthetics, as has been the case with the pharma industry in the last 60 years.

    However,I was talking more about the active incredients being synthesised via biotechnological means or via modified plant strains not pure chemical synthesis,although this incurs another set of hoops to jump though. OTH,I am thinking more of large scale production which would drop down costs.

    Also ,TBH you also need consider what cells are being targeted by the active compound mentioned in the study. Smoking plant extracts or inhaling them might not be the best way forward for delivery of the compound. You really cannot make a one size fits all judgement for drug delivery,especially with new derivatives being released over time.

    I am more interested in the active incredients and not the plant or its flowers as that is what is doing the job. I am happier that I can take a disprin or aspirin instead of having to boil some willow bark,plus they are more affective.

    You have to remember lab tests,only test whether a compound can actually have an effect in an ideal situation. OTH,whether the compound in the OP will be truely effective in actual trials in targeting cancer cells is another question as you ideally want as much of the drug to target ONLY the affected tissue. OTH,for treating other conditions,you might find alternate delivery methods work well.You might find that targeting is an issue in a host environment,quantities of the drugs found to have an effect are actual toxic to many people or simply the compound is too quickly degraded in the host environment.

    This is one of the reasons why drug development costs so much. Loads of compounds or extracts work well in the lab(and tens of thousands of potential candidates can be screened),but issues with toxity,side effects,targetting issues and even the cost of scaling up production to profitable levels really reduce the number of viable candidates.

    Edit!!

    An example of a modified plant strain:

    http://blogs.wsj.com/law/2012/07/06/...ess-marijuana/

    Much reduced THC,but much higher levels of CBD which is relevant for the study in the OP.
    Last edited by CAT-THE-FIFTH; 26-09-2012 at 01:56 PM.

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