Results 1 to 16 of 16

Thread: AI platform helps bring to light a powerful new antibiotic

  1. #1
    HEXUS.admin
    Join Date
    Apr 2005
    Posts
    31,709
    Thanks
    0
    Thanked
    2,073 times in 719 posts

    AI platform helps bring to light a powerful new antibiotic

    Halicin can kill some of the most dangerous antibiotic-resistant pathogens.
    Read more.

  2. #2
    Super Moderator Jonj1611's Avatar
    Join Date
    Jun 2008
    Posts
    5,192
    Thanks
    1,455
    Thanked
    856 times in 651 posts

    Re: AI platform helps bring to light a powerful new antibiotic

    An excellent use of AI, unlike that other fad of creating dinosaurs pffft
    Jon

  3. #3
    Senior Member
    Join Date
    Mar 2019
    Location
    Northants
    Posts
    309
    Thanks
    4
    Thanked
    22 times in 19 posts
    • KultiVator's system
      • Motherboard:
      • Aorus x570 Ultra
      • CPU:
      • Ryzen 3900x
      • Memory:
      • G.Skill 32GB (2x16gb) 3600Mhz
      • Storage:
      • 5TB of NVMe storage (most of it on PCIe4) + Various SATA SSDs & HDDs
      • Graphics card(s):
      • Aorus RTX 2080 Super OC 8GB
      • PSU:
      • Corsair RM750x
      • Case:
      • Phanteks Eclipse P600s (Black & White Edition)
      • Operating System:
      • Windows 10 Pro
      • Monitor(s):
      • AOC 32" 4K IPS / ASUS 24" ProArt 1200p IPS / GStory 1080p/166Hz GSync/FreeSync IPS / Quest 2 HMD

    Re: AI platform helps bring to light a powerful new antibiotic

    Interesting and well-written article - good to hear about tech's reach into important areas of life that can affect us all.

    This approach has to beat the current random scouring of caves and the sea-bed by scientists, all in the hope of stumbling across new naturally-occurring anti-biotics (without a lot of success, so far).

  4. #4
    Senior Member
    Join Date
    Mar 2009
    Location
    Manchester
    Posts
    1,522
    Thanks
    28
    Thanked
    89 times in 72 posts
    • Percy1983's system
      • Motherboard:
      • Gigabyte x570 Aorus Pro
      • CPU:
      • AMD 3700x + Cooler Master Nepton 140XL
      • Memory:
      • 64GB (4x16GB ) Corsair Vengence 3200mhz @ 3600mhz CL16
      • Storage:
      • 500GB Silicon Power NVME + 2x 4tb Raid 0 (2tbx2) arrays with 250gb Silicon Power NVME cache
      • Graphics card(s):
      • R9 290 4GB
      • PSU:
      • 875w Thermaltake Toughpower XT
      • Case:
      • Thermaltake Level 10 GT Snow Edition
      • Operating System:
      • Windows 10 Pro 64bit
      • Monitor(s):
      • 24" Acer UHD x2
      • Internet:
      • Talk Talk!

    Re: AI platform helps bring to light a powerful new antibiotic

    To think all that processing which has gone into bitcoin could have figured this years ago.

  5. Received thanks from:

    mtyson (21-02-2020),Sumanji (23-02-2020)

  6. #5
    Member
    Join Date
    Feb 2015
    Posts
    122
    Thanks
    12
    Thanked
    2 times in 2 posts

    Re: AI platform helps bring to light a powerful new antibiotic

    Fantastic!

  7. #6
    Banhammer in peace PeterB kalniel's Avatar
    Join Date
    Aug 2005
    Posts
    30,893
    Thanks
    1,839
    Thanked
    3,340 times in 2,684 posts
    • kalniel's system
      • Motherboard:
      • Gigabyte Z390 Aorus Ultra
      • CPU:
      • Intel i9 9900k
      • Memory:
      • 32GB DDR4 3200 CL16
      • Storage:
      • 1TB Samsung 970Evo+ NVMe
      • Graphics card(s):
      • nVidia GTX 1060 6GB
      • PSU:
      • Seasonic 600W
      • Case:
      • Cooler Master HAF 912
      • Operating System:
      • Win 10 Pro x64
      • Monitor(s):
      • Dell S2721DGF
      • Internet:
      • rubbish

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by hexus
    It would have been interesting to find out what hardware / software the MIT researchers used to aid them in their task but nothing specific was mentioned in the news release, or when I dug further.
    Chemprop.
    https://github.com/chemprop/chemprop

  8. Received thanks from:

    mtyson (21-02-2020)

  9. #7
    Long member
    Join Date
    Apr 2008
    Posts
    2,427
    Thanks
    70
    Thanked
    404 times in 291 posts
    • philehidiot's system
      • Motherboard:
      • Father's bored
      • CPU:
      • Cockroach brain V0.1
      • Memory:
      • Innebriated, unwritten
      • Storage:
      • Big Yellow Self Storage
      • Graphics card(s):
      • Semi chewed Crayola Mega Pack
      • PSU:
      • 20KW single phase direct grid supply
      • Case:
      • Closed, Open, Cold
      • Operating System:
      • Cockroach
      • Monitor(s):
      • The mental health nurses
      • Internet:
      • Please.

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by Percy1983 View Post
    To think all that processing which has gone into bitcoin could have figured this years ago.
    Just think of all the processing which has gone into this which could have gone into Bitcoin.

    Interestingly this is probably also a product of all that health data which has been given to Google to help with projects like this. To much whinging and whining.

  10. #8
    Banhammer in peace PeterB kalniel's Avatar
    Join Date
    Aug 2005
    Posts
    30,893
    Thanks
    1,839
    Thanked
    3,340 times in 2,684 posts
    • kalniel's system
      • Motherboard:
      • Gigabyte Z390 Aorus Ultra
      • CPU:
      • Intel i9 9900k
      • Memory:
      • 32GB DDR4 3200 CL16
      • Storage:
      • 1TB Samsung 970Evo+ NVMe
      • Graphics card(s):
      • nVidia GTX 1060 6GB
      • PSU:
      • Seasonic 600W
      • Case:
      • Cooler Master HAF 912
      • Operating System:
      • Win 10 Pro x64
      • Monitor(s):
      • Dell S2721DGF
      • Internet:
      • rubbish

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by philehidiot View Post
    Interestingly this is probably also a product of all that health data which has been given to Google to help with projects like this. To much whinging and whining.
    Nope. This is a relatively simple application of machine learning, no human data involved other than existing reference sets of drugs approved for use and compound/toxicity databases.
    Last edited by kalniel; 21-02-2020 at 02:22 PM.

  11. Received thanks from:

    Jonj1611 (21-02-2020)

  12. #9
    Long member
    Join Date
    Apr 2008
    Posts
    2,427
    Thanks
    70
    Thanked
    404 times in 291 posts
    • philehidiot's system
      • Motherboard:
      • Father's bored
      • CPU:
      • Cockroach brain V0.1
      • Memory:
      • Innebriated, unwritten
      • Storage:
      • Big Yellow Self Storage
      • Graphics card(s):
      • Semi chewed Crayola Mega Pack
      • PSU:
      • 20KW single phase direct grid supply
      • Case:
      • Closed, Open, Cold
      • Operating System:
      • Cockroach
      • Monitor(s):
      • The mental health nurses
      • Internet:
      • Please.

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by kalniel View Post
    Nope. This is a relatively simple application of ML, no human data involved other than existing reference sets of drugs approved for use and compound/toxicity databases.
    Absolutely no reference to the large datasets of lab test results to see which other antibiotics are effective against which diseases? I find that unlikely but I'm open to being educated.

  13. #10
    Banhammer in peace PeterB kalniel's Avatar
    Join Date
    Aug 2005
    Posts
    30,893
    Thanks
    1,839
    Thanked
    3,340 times in 2,684 posts
    • kalniel's system
      • Motherboard:
      • Gigabyte Z390 Aorus Ultra
      • CPU:
      • Intel i9 9900k
      • Memory:
      • 32GB DDR4 3200 CL16
      • Storage:
      • 1TB Samsung 970Evo+ NVMe
      • Graphics card(s):
      • nVidia GTX 1060 6GB
      • PSU:
      • Seasonic 600W
      • Case:
      • Cooler Master HAF 912
      • Operating System:
      • Win 10 Pro x64
      • Monitor(s):
      • Dell S2721DGF
      • Internet:
      • rubbish

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by philehidiot View Post
    Absolutely no reference to the large datasets of lab test results to see which other antibiotics are effective against which diseases? I find that unlikely but I'm open to being educated.
    They don't need human data to find out if an antibiotic works against a particular bacterial species. Remember they're not clinically trialing anything here, but they are selecting from pre-existing compounds. The drug they found is being investigated for diabetes for example.
    Last edited by kalniel; 21-02-2020 at 02:44 PM.

  14. #11
    Banhammer in peace PeterB kalniel's Avatar
    Join Date
    Aug 2005
    Posts
    30,893
    Thanks
    1,839
    Thanked
    3,340 times in 2,684 posts
    • kalniel's system
      • Motherboard:
      • Gigabyte Z390 Aorus Ultra
      • CPU:
      • Intel i9 9900k
      • Memory:
      • 32GB DDR4 3200 CL16
      • Storage:
      • 1TB Samsung 970Evo+ NVMe
      • Graphics card(s):
      • nVidia GTX 1060 6GB
      • PSU:
      • Seasonic 600W
      • Case:
      • Cooler Master HAF 912
      • Operating System:
      • Win 10 Pro x64
      • Monitor(s):
      • Dell S2721DGF
      • Internet:
      • rubbish

    Re: AI platform helps bring to light a powerful new antibiotic

    And by relatively simple, I don't mean easy or not clever - primary neat bit in my opinion is how they represented molecules to train the neural network - previously neural nets have failed to be all that great at picking out relevant chemical structural features (I know, I tried to do them for protein molecules years ago), but these guys have found a way of representing the information that's useful. Once they've got that the classification bit is fairly normal, but then they've also done good investigative work in the lab trying to work out how the drug they've identified actually creates it's anti-bacterial effect, and therefore discover a novel action which might open the gates to further drug developments even by conventional means.

  15. Received thanks from:

    mtyson (21-02-2020)

  16. #12
    MCRN Tachi Ttaskmaster's Avatar
    Join Date
    Nov 2013
    Location
    Reading, UK
    Posts
    6,835
    Thanks
    560
    Thanked
    777 times in 651 posts
    • Ttaskmaster's system
      • Motherboard:
      • Asus X99-PRO USB 3.1
      • CPU:
      • i7 5960X o/c to 4.6GHz
      • Memory:
      • 32GB 3200MHz Crucial Ballistix Tactical Tracer RGB DDR4
      • Storage:
      • Samsung Evo 120GB and Seagate Baracuda 2TB
      • Graphics card(s):
      • Gigabyte G1 GTX980Ti
      • PSU:
      • EVGA Supernova G2 1000W
      • Case:
      • Phanteks Enthoo Luxe wiv perspex window
      • Operating System:
      • Win10 64 Home
      • Monitor(s):
      • Acer Predator XB270HU 1440 IPS GSync 144Hz
      • Internet:
      • 900Mbps Gigaclear WHOOOOOOOOOOOO!!!!!!!!

    Re: AI platform helps bring to light a powerful new antibiotic

    OK, so how long before that AI decides humans are the highest threat pathogen on the planet?
    _______________________________________________________________________
    Quote Originally Posted by Mark Tyson
    like a chihuahua urinating on a towering inferno...

  17. #13
    Banhammer in peace PeterB kalniel's Avatar
    Join Date
    Aug 2005
    Posts
    30,893
    Thanks
    1,839
    Thanked
    3,340 times in 2,684 posts
    • kalniel's system
      • Motherboard:
      • Gigabyte Z390 Aorus Ultra
      • CPU:
      • Intel i9 9900k
      • Memory:
      • 32GB DDR4 3200 CL16
      • Storage:
      • 1TB Samsung 970Evo+ NVMe
      • Graphics card(s):
      • nVidia GTX 1060 6GB
      • PSU:
      • Seasonic 600W
      • Case:
      • Cooler Master HAF 912
      • Operating System:
      • Win 10 Pro x64
      • Monitor(s):
      • Dell S2721DGF
      • Internet:
      • rubbish

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by Ttaskmaster View Post
    OK, so how long before that AI decides humans are the highest threat pathogen on the planet?
    If you ask the right (wrong) question, you'll get that answer

  18. #14
    MCRN Tachi Ttaskmaster's Avatar
    Join Date
    Nov 2013
    Location
    Reading, UK
    Posts
    6,835
    Thanks
    560
    Thanked
    777 times in 651 posts
    • Ttaskmaster's system
      • Motherboard:
      • Asus X99-PRO USB 3.1
      • CPU:
      • i7 5960X o/c to 4.6GHz
      • Memory:
      • 32GB 3200MHz Crucial Ballistix Tactical Tracer RGB DDR4
      • Storage:
      • Samsung Evo 120GB and Seagate Baracuda 2TB
      • Graphics card(s):
      • Gigabyte G1 GTX980Ti
      • PSU:
      • EVGA Supernova G2 1000W
      • Case:
      • Phanteks Enthoo Luxe wiv perspex window
      • Operating System:
      • Win10 64 Home
      • Monitor(s):
      • Acer Predator XB270HU 1440 IPS GSync 144Hz
      • Internet:
      • 900Mbps Gigaclear WHOOOOOOOOOOOO!!!!!!!!

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by kalniel View Post
    If you ask the right (wrong) question, you'll get that answer
    _______________________________________________________________________
    Quote Originally Posted by Mark Tyson
    like a chihuahua urinating on a towering inferno...

  19. Received thanks from:

    kalniel (21-02-2020)

  20. #15
    Senior Member
    Join Date
    May 2009
    Location
    Where you are not
    Posts
    1,264
    Thanks
    559
    Thanked
    92 times in 81 posts
    • Iota's system
      • Motherboard:
      • Asus Maximus Hero XI
      • CPU:
      • Intel Core i9 9900KF
      • Memory:
      • CMD32GX4M2C3200C16
      • Storage:
      • 1 x 250GB / 1 x 1TB / 1 x 2TB Samsung 970 Evo Plus NVMe
      • Graphics card(s):
      • Nvidia RTX 3090 Founders Edition
      • PSU:
      • Corsair HX1200i
      • Case:
      • Corsair Obsidian 500D
      • Operating System:
      • Windows 10 Pro 64-bit
      • Monitor(s):
      • Samsung Odyssey G9
      • Internet:
      • 40Mbps SKY Fibre

    Re: AI platform helps bring to light a powerful new antibiotic

    Quote Originally Posted by kalniel View Post
    If you ask the right (wrong) question, you'll get that answer
    Ah, but can you trust the answer even if you ask the right (wrong) question?

    HAL : I know I've made some very poor decisions recently, but I can give you my complete assurance that my work will be back to normal. I've still got the greatest enthusiasm and confidence in the mission. And I want to help you.

  21. Received thanks from:

    kalniel (21-02-2020)

  22. #16
    Banhammer in peace PeterB kalniel's Avatar
    Join Date
    Aug 2005
    Posts
    30,893
    Thanks
    1,839
    Thanked
    3,340 times in 2,684 posts
    • kalniel's system
      • Motherboard:
      • Gigabyte Z390 Aorus Ultra
      • CPU:
      • Intel i9 9900k
      • Memory:
      • 32GB DDR4 3200 CL16
      • Storage:
      • 1TB Samsung 970Evo+ NVMe
      • Graphics card(s):
      • nVidia GTX 1060 6GB
      • PSU:
      • Seasonic 600W
      • Case:
      • Cooler Master HAF 912
      • Operating System:
      • Win 10 Pro x64
      • Monitor(s):
      • Dell S2721DGF
      • Internet:
      • rubbish

    Re: AI platform helps bring to light a powerful new antibiotic

    ^nice link back to the name of the compound

    I used that line once with a boss I didn't get on with. They didn't get the reference (not that I was being serious, so probably a good thing)

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •