The HD5000 series were also PCI-E 2.1 too but would run fine in most motherboards fine.
Edit!!
I would go for the cheaper X3 445
TBH as the X3 450 is not worth another £8 to £9 extra
IMHO.
The money saved would be better spent on the following motherboard:
http://www.ebuyer.com/product/205849
It has USB3.0 and SATA3.0!
However,the MSI 870-C45 would still the job fine even though it uses an older chipset. The similar MSI 770-C45 with an HD6850 1GB is recommended by Bit tech as part of their current budget build specification.