In fact, I don't think I've found any pre-set profile for a game that has been any different to using a normal £10 keyboard, as far as the keys go. Nothing has come with anything programmed in to the extra G-Keys and regardless of which of the three User profile buttons I switch between. It just seems to affect what is displayed on the LCD screen.
On the mouse, it works the same and depends what you have set the G keys to do in the first place.
For example, in my games I always have G10 mapped to the 'I' key and then set the games up for 'I' to be the Reload command.
If you have G10 set to 'I', but in your game settings the 'I' by default opens your inventory, then no it won't work...
TBH, I'm not sure what the pre-set game profiles are supposed to do and I always end up changing the in-game keybinds to what I want anyway, so I'd recommend just setting your mouse keys to whichever keys and macros you might want, then just configuring the game itself.
I generally have IOP, KL and NM mapped to the gaming profile, with the profile selector to switch between my different user profiles for other apps.