I have a 290 with dual screens and I have noticed the PSU making a noise like a HDD when scrolling.
I have turned off mouse smoothing, and this has reduced it when scrolling but sill happens when using the middle mouse button to scroll.
I have read that it is noting to worry about, but its more the annoyance than worry.
Is this the power supply? or is it something else?
edit:
Its a corsair TX650 v1, seems to be a common complaint re:coil whine.