Not according to NZXT: http://www.nzxt.com/product/detail/110-lexa-s-case
But from what I can see, you haven't listed ANY kind of cooler for the CPU?
AFAIK, that is a pretty essential item...
There *is* no setup!
This isn't a self-assembly, custom water loop I'm talking about, it's a one-piece unit, pre-built that you just take out of the box and plug directly in to your case.
It usually costs a lot less than many of the decent air coolers (mine cost half that of the decent Noctua fans), outperforms many of them and takes up far less space on your motherboard.
The included instructions are just about idiot-proof as well (even I managed it with no problems!), so you're all good.
I'm pretty certain, yes.
The sealed units will work in just about any case that has space to accomodate them. Most cases can manage a single-fan one, as you just put the radiator in front of the usual exhaust fan at the top of the rear panel. The Lexa has one at the rear top and two spaces in the roof it could go.
The four long screws go through the back panel, through the fan and fix into the radiator, which holds it all in place.
The cooler unit goes on to the motherboard just like any other.
The fan plugs in to the cooler unit.
The power and PWM leads from the cooler plug in to the motherboard headers.
That is how complicated it gets.
Some have buttons on the front to alter the cooling profile (low, medium and high), while others have software that you can play with.
But basically, even if you don't install the software at all, it still works off the motherboard just like a normal cooler.