TBH I haven't really had to tinker much with SLi. The big games usually pretty much launch with profiles or they're in the drivers right away.
The most problems I've had were when Vista launched, or when I was using Quad SLi when it was first developed. By and large, early months on Vista notwithstanding, 2 way SLi has been very hands off. With my GTX295s I never touch anything.
CF has had more compatibility issues, and you still have to wait for profiles on some games or hack around with them because ATi chooses fewer games to invest dev relations into, but they are much better now than years gone by.
In any case, the money in question here has already been spent. He has a far better rig than any single GPU set except a 5870, and it's too close to call there. A 5850 would be a big step down.