Just thought this subject might make an interesting thread.
For me it was an MSI K8N neo2 platinum motherboard. When I first got it had loads of problems trying to install an OS because the hard drives kept disappearing from BIOS, which I later found out was because there was a compatibility issue with Nvidia SATA controller and the drives I was using.
And the final straw was when Nvidia decided that they would not do any Vista drivers for the Nforce3 chipsets.