Not at all.
Unleash mode is for unleashing cores full stop. So that's the one you want I can't remember the exact BIOS settings available or which version my BIOS is (and my step-son's playing flash games on the HTPC at the minute so I can't check!) but basically make sure one of the ACC modes is selected (Auto is fine), then set Unleashing Mode to enabled. Reboot, and presto, Athlon X2 for the price of a Sempron!
EDIT: I should also mention - I have Cool & Quiet enabled and didn't encounter any issues running the CPU unlocked @ stock voltage with Cool & Quiet.
@ Terbinator / Ulti: the MSI board has better phase switching than the ASUS EVO I've got iirc, so if you're bothered about power consumption that's a good one to go for. Someone on here's got one and was getting ~ 30% lower power draw than me with basically the same components...
Last edited by scaryjim; 23-01-2010 at 10:11 PM.
Sorry for double posting but to add my experience...
the Sempron unlocked stably @ stock volts (i.e. Auto in Bios, read @ ~ 1.32V in CPUZ) to Athlon X2 4400e. I then undervolted to 1.05V in BIOS. The Sempron is completely stable as a single core - it ran unlocked @ 1.05V for a while then developed instability, including random crashes during flash video playback and occasional failure to boot. I've now gone back to running it undervolted as a single core as I'm more concerned about reducing power draw than performance for that machine.
One thing I will say is that I've heard some MSI boards don't allow undervolting - if you really want to lower power draw you might want to consider that. Then again, if you really want to reduce power draw you don't want to unlock the second core, as it does draw significantly more power at load with it unlocked (interestingly, it draws no more power at idle if you have Cool & Quiet turned on).
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