Not just 2TB and larger, smaller ones too, I have a WD 800GB drive thats 4k sector size, and you either have to set the jumper or run some utility to ensure things are aligned correctly.
You can also do the same thing manually, I believe, but I dont know if its only on some OSes, or requires certain drivers.
I know that Windows 7, at least initially, requires that you use the Microsoft default drivers for TRIM to work, Intel or other chipset makers might have updated their drivers to work but tbh, I havent checked.