On my workstation, my entire user folder is on a RAID1 of a couple of 500GB WD RE4 drives.
Anything particularly important is shoved into my Dropbox, which syncs with my laptop, workstation and mobile phone.
Photo's I take on my phone automatically go into Dropbox and sync to my Google+ account.
I run a couple of Minecraft servers, which also run from a couple of WD RE4 drives and are backed up hourly to a cheap 2TB drive.
I don't run full system backups. Would rather just reinstall my OS if anything happens.