Firstly, if it's an AMD rig the memory controller is only officially rated to 1333MHz, regardless of what the motherboard claims. It may be able to cope with running the RAM faster than that, but officially 1600MHz is out of spec! Secondly, make sure the RAM is running at its rated voltage: it may well only be rated to 8-8-8- at 1.65V or higher, and the motherboard may be running it at a lower voltage.