Originally Posted by
nameinuse
So, for example, with local OWA access, you'd add the record owa.company.com on your DC to point to the local address the interface is hosted on and configure the address as a proxy exception in Group Policy. For external access, you'd forward everything that came in on that port or IP address to the appropriate box internally (though this does depend on you having the normal NAT router setup - if it's an odd topology you're working with, let me know).
Not sure how much of what you asked that covers, but should be a start...