I know we keep saying stuff along the same lines, but the new consoles might help reduce heavy use of legacy instructions in games.
Also, I wonder what this means for PhysX?
AFAIK it's used in some form on current consoles, but use on next consoles would likely mean either porting to GCN or using a code-path from this century on the CPU, either of which could carry over to desktop. Either that, or just not bother with it at all; the GPU bit only really adds some particle effects and there are plenty of other, more open, engines to choose from.